The Suzuki-Miyaura cross-coupling reactions of 6-halopurines with boronic acids leading to 6-aryl- and 6-alkenylpurines

The Suzuki-Myiaura cross-coupling reactions of 9-benzyl-6-chloropurine with boronic acids gave 6-alkylated purines in moderate to excellent yields. Th e best results with electron rich arylboronic acids were obtained in toluen e in the presence of anhydrous K2CO3 as a base, while electron poor boronic acids and alkenyl boronic acids gave better results using aqueous K2CO3 in DME. The reaction was successfully applied for the synthesis of 6-phenylpu rine bases and nucleosides.