Synthesis of iPF(2 alpha)-V: a new route

We are reporting here on a new synthesis of iPF(2 alpha)-V, and we also dis close the first report on the synthesis of 12-epi-iPF(2 alpha)-V. The new t otal synthesis of iPF(2 alpha)-V reported here is designed to address metab olism and analytical issues. We have used this new route and also performed the total synthesis of 17,17,18,18-tetradeutero-iPF(2 alpha)-V. The availa bility of the deuterated analog of iPF(2 alpha)-V is the first step in our attempt to quantitate this isoprostane in biological fluids by GC and LC-MS . (C) 1999 Elsevier Science Ltd. All rights reserved.