A new linker for the synthesis of C-terminal peptide alpha-oxo-aldehydes

Authors
Fruchart, JS Gras-Masse, H Melnyk, O
Citation
Js. Fruchart et al., A new linker for the synthesis of C-terminal peptide alpha-oxo-aldehydes, TETRAHEDR L, 40(34), 1999, pp. 6225-6228
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
34
Year of publication
1999
Pages
6225 - 6228
Database
ISI
SICI code
0040-4039(19990820)40:34<6225:ANLFTS>2.0.ZU;2-U
Abstract
A tartaric acid-based linker was elaborated on an amino PEGA resin for the synthesis of C-terminal alpha-oxoaldehydes. A solid phase periodic oxidatio n allowed the formation of the glyoxylyl moiety and the separation of the f inal product from the solid support. (C) 1999 Elsevier Science Ltd. All rig hts reserved.