Chemoenzymatic synthesis of 1 alpha,24(R)-dihydroxycholesterol

Authors
Oshida, J Okamoto, M Azuma, S
Citation
J. Oshida et al., Chemoenzymatic synthesis of 1 alpha,24(R)-dihydroxycholesterol, TETRAHEDR-A, 10(12), 1999, pp. 2337-2342
Citations number
28
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
12
Year of publication
1999
Pages
2337 - 2342
Database
ISI
SICI code
0957-4166(19990618)10:12<2337:CSO1A>2.0.ZU;2-O
Abstract
1 alpha,24(R)-Dihydroxycholesterol, which is the key intermediate for the s ynthesis of 1 alpha,24(R)-dihydroxyvitamin D-3, was effectively synthesized via stereoselective esterification of the 24(R)-hydroxy group using a lipa se in combination with inversion of configuration of the 24(S)-hydroxy grou p using the Mitsunobu reaction (R:S=99:1). (C) 1999 Elsevier Science Ltd. A ll rights reserved.