This paper proposes a dynamic multi-regional growth model with free mo
bility of capital and population. The economic system consists of mult
iple cities interconnected by high-speed railway systems with each cit
y consisting of one production sector as well as residential land use.
The railway systems provide production sectors of different cities wi
th the opportunity of face-to-face communication for knowledge product
ion. The model describes the dynamic interdependence between capital a
nd knowledge accumulation, wage and land rent structures, urban patter
ns with endogenous city size and inter-city interactability. It is emp
hasized how differences in geographic and qualitative factors of high-
speed railway systems may affect regional economic development. The mo
del simulates the dynamic processes of economic development of city sy
stems.