The ankyrin repeat: a diversity of interactions on a common structural framework

Authors
Sedgwick, SG Smerdon, SJ
Citation
Sg. Sedgwick et Sj. Smerdon, The ankyrin repeat: a diversity of interactions on a common structural framework, TRENDS BIOC, 24(8), 1999, pp. 311-316
Citations number
32
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
24
Issue
8
Year of publication
1999
Pages
311 - 316
Database
ISI
SICI code
0968-0004(199908)24:8<311:TARADO>2.0.ZU;2-N
Abstract
The ankyrin repeat is one of the most common protein sequence motifs. Recen t X-ray and MMR structures of ankyrin-repeat proteins and their complexes h ave provided invaluable insights into the molecular basis of the extraordin ary variety of biological activities of these molecules. In particular, the y have begun to reveal how a large family of structurally related proteins can interact specifically with such a diverse array of macromolecular targe ts.