Mammalian Kruppel-like transcription factors: more than just a pretty finger

Authors
Turner, J Crossley, M
Citation
J. Turner et M. Crossley, Mammalian Kruppel-like transcription factors: more than just a pretty finger, TRENDS BIOC, 24(6), 1999, pp. 236-241
Citations number
41
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
24
Issue
6
Year of publication
1999
Pages
236 - 241
Database
ISI
SICI code
0968-0004(199906)24:6<236:MKTFMT>2.0.ZU;2-V
Abstract
The transcription factor SP1 contains three Kruppel-like zinc fingers. Rece ntly, several related proteins, including erythroid, lung and gut-enriched Kruppel-like factors, have been identified. Together with SP1, these protei ns form a sizeable family of transcription factors that share homology in t heir zinc-finger domains but differ elsewhere. Analysis of these difference s is illuminating specific mechanisms by which transcription is regulated.