Giant-cell tumors (osteoclastomas) of the sphenoid body are rare, histologi
cally benign lesions that can grow in different directions within the bony
structures of the skull base. To date, the precise role of the different su
rgical strategies (radical versus partial resection; biopsy) and of supplem
entary postoperative radiotherapy remains undefined due to the short follow
-up of the majority of the reported cases. We present a patient who is aliv
e without symptoms or signs of recurrence 44 years after a macroscopically
radical excision of the neoplasm followed by radiotherapy.