Evaluation of the effects of desmopressin in acute ureteral obstruction

Objective: To evaluate the effects of desmopressin on pressure values insid e the pelvis and ureter of the rat following acute obstruction. Materials a nd Methods: By means of a microsurgical technique, 24 male Wistar mts were submitted to ureteral obstruction; pressure inside the ureter was recorded using a cannula and a micrometric glass column. In the treatment group (14 animals) 6 mg/kg of desmopressin were administered 30 min before the beginn ing of the experiment. Results:Rats pretreated with desmopressin showed a s tatistically significant reduction in mean intraureteral pressure following acute obstruction (p = 0.05). Conclusions: In Wistar rats desmopressin dem onstrated a powerful antidiuretic effect, reducing the intraureteral pressu re. The experimental model is useful for a better understanding of physiopa thology of renal colic and acute obstruction.