Conservative measures are the mainstay of therapy in adult polycystic kidne
y disease (APKD). Pain, infection and obstructive uropathy are the major in
dications for intervention. Chronic pain has been treated with narcotic ana
lgesics, needle aspiration of dominant cysts, and open renal cyst decortica
tion. Laparoscopic cyst decortication, by either transperitoneal or retrope
ritoneal ac; cess, is a new emerging option with similar efficacy to open s
urgery and less morbidity. Cyst infection in these patients responds poorly
to commonly used antibiotics. Patients with refractory cyst infection may
even require nephrectomy. Herein, we present 2 cases with APKD that were tr
eated by retroperitoneoscopic decortication for painful and infected cysts.
Both patients showed prompt and sustained improvement in symptoms, with mi
nimal morbidity and short convalescence. This approach has not hitherto bee
n described for infected cysts in APKD. The retroperitoneoscopic route shou
ld be preferred in the presence of infected cysts so as to prevent intraper
itoneal contamination.