GETTING IT TOGETHER - SIGNAL-TRANSDUCTION IN G-PROTEIN COUPLED RECEPTORS BY ASSOCIATION OF RECEPTOR DOMAINS

The mechanism of signal transduction by G-protein coupled receptors is unknown. Here, we propose that these receptors signal in a way that i s qualitatively similar to that seen in the chemokine and endocrine ho rmone receptor families; the signal occurs when two domains of the rec eptor are brought together, although this is not the only requirement for signaling.