UNDERSTANDING ENZYMATIC CATALYSIS - THE IMPORTANCE OF SHORT, STRONG HYDROGEN-BONDS

Authors
GERLT JA KREEVOY MM CLELAND WW FREY PA
Citation
Ja. Gerlt et al., UNDERSTANDING ENZYMATIC CATALYSIS - THE IMPORTANCE OF SHORT, STRONG HYDROGEN-BONDS, Chemistry & biology, 4(4), 1997, pp. 259-267
Citations number
63
Categorie Soggetti
Biology
Journal title
Chemistry & biology → ACNP
ISSN journal
10745521
Volume
4
Issue
4
Year of publication
1997
Pages
259 - 267
Database
ISI
SICI code
1074-5521(1997)4:4<259:UEC-TI>2.0.ZU;2-T
Abstract
We have proposed previously that short, strong hydrogen bonds exist in enzyme active sites and that they are important in explaining enzymic rate enhancements. Here, we defend this proposal and provide evidence for likely changes of hydrogen bond strengths during enzymic catalysi s.