Diuretic-induced hyponatremia

Diuretics are one of the most common causes of severe hyponatremia. Yet, de spite several relevant studies and years of clinical experience, the mechan ism and optimal treatment of diuretic-induced hyponatremia remain unclear. What is clear is that most cases are caused by thiazide rather than loop di uretics and that severe hyponatremia can develop very rapidly in susceptibl e patients. In this review, I will discuss the pathogenesis, clinical featu res, prevention, and treatment of diuretic-induced hyponatremia in the hope that increased awareness and understanding will reduce the incidence and c omplications of this potentially life-threatening syndrome.