Direct flow injection chemiluminescence determination of salicylamide

A new direct flow injection chemiluminescence method is proposed for the de termination of salicylamide, based upon the oxidation of the drug by potass ium permanganate in dilute sulphuric acid. The calibration graph is linear over the range 20 ng ml(-1) (30 limit of detection)-8 mu g ml(-1) salicylam ide, with a relative standard deviation (n=50, 0.5 mu g ml(-1)) of 1.7%. Th e average sample insertion rate is 142 h(-1). The influence of relevant for eign compounds is found to be relatively slight. The method is applied to t he determination of salicylamide in a pharmaceutical formulation and human urine. (C) 1999 Elsevier Science B.V. All rights reserved.