Hybrid carcinomas of salivary glands - Report of 4 cases and review of theliterature

Objective.-To report 4 cases of hybrid carcinoma and to review the literatu re on these rare neoplasms of the salivary gland. Methods.-Hematoxylin-eosin-stained, formalin-fixed, paraffin-embedded tissu e sections from 3 parotid tumors and 1 palate tumor were examined. Results.-The cases were classified as adenoid cystic and mucoepidermoid car cinoma, adenoid cystic and epithelial-myoepithelial carcinoma, epithelial-m yoepithelial and salivary duct carcinoma, and adenoid cystic and salivary d uct carcinoma. All patients were men, 28 to 71 years old; 3 patients presen ted with parotid mass, and 1 patient presented with palatal mass. One patie nt presented with facial nerve paralysis and pain. The soft palatal tumor w as a slowly growing mass with maxillary sinus involvement at the time of th e diagnosis. All patients were treated with surgery and radiotherapy. Conclusions.-Correct identification of 2 or more neoplastic entities will h elp assess the aggressiveness and metastatic potential of the tumor and inf luence the clinical course and treatment.