Lymphoepithelioma-like carcinoma of the colon in a patient with hereditarynonpolyposis colorectal cancer

Tumors with features similar to those of nasopharyngeal carcinoma, so-calle d lymphoepithelioma-like carcinomas, have been described in several organs but are extremely rare in the colon. We describe a patient with a family hi story consistent with hereditary nonpolyposis colorectal cancer who had 3 m alignant lesions in the right colon, namely, a mucinous cancer, a lymphoepi thelioma-like carcinoma, and a well-differentiated adenocarcinoma with prom inent lymphoid stroma. To the best of our knowledge, lymphoepithelioma-like carcinoma has not been described previously in hereditary nonpolyposis col orectal cancer.