We explore the sensitivity of the nucleosynthesis of intermediate-mass elem
ents (28 less than or equal to A less than or similar to 80) in supernovae
derived from massive stars to the nuclear reaction rates employed in the mo
del. Two standard sources of reaction rate data are employed in pairs of ca
lculations that are otherwise identical. Both include as a common backbone
the experimental reactions rates of Caughlan & Fowler. Two stellar models a
re calculated for each of two masses: 15 and 25 M.. Each star is evolved fr
om core hydrogen burning to a presupernova state carrying an appropriately
large reaction network and then exploded using a piston near the edge of th
e iron core as described by Woosley & Weaver. The final stellar yields from
the models calculated with the two rate sets are compared and found to dif
fer in most cases by less than a factor of 2 over the entire range of nucle
i studied. Reasons for the major discrepancies along with the physics under
lying the two reaction rate sets employed are discussed in detail. The nucl
eosynthesis results are relatively robust and less sensitive than might be
expected to uncertainties in nuclear reaction rates, though they are sensit
ive to the stellar model employed.