S. Estil et al., UVB-INDUCED FORMATION OF (6-4)PHOTOPRODUCTS IN THE RAT CORNEAL EPITHELIUM, Acta ophthalmologica Scandinavica, 75(2), 1997, pp. 120-123
The induction of DNA photoproducts in rat corneal epithelium was studi
ed after in vivo exposure to different doses of ultraviolet B light at
297 nm. Affinity-purified antibodies with a major specificity against
UV-induced (6-4) photoproducts were used. The results indicate a dose
dependent formation of (6-4) photoproducts. Even a minimal erythema d
ose (25 mJ/cm(2)) produced (6-4) photoproducts, demonstrating that DNA
damage occurs in corneal tissue following exposure to biologically re
levant doses of UVB light.