UVB-INDUCED FORMATION OF (6-4)PHOTOPRODUCTS IN THE RAT CORNEAL EPITHELIUM

Authors
ESTIL S OLSEN WM HUITFELDT HS HAASKJOLD E
Citation
S. Estil et al., UVB-INDUCED FORMATION OF (6-4)PHOTOPRODUCTS IN THE RAT CORNEAL EPITHELIUM, Acta ophthalmologica Scandinavica, 75(2), 1997, pp. 120-123
Citations number
42
Categorie Soggetti
Ophthalmology
Journal title
Acta ophthalmologica Scandinavica → ACNP
ISSN journal
13953907
Volume
75
Issue
2
Year of publication
1997
Pages
120 - 123
Database
ISI
SICI code
1395-3907(1997)75:2<120:UFO(IT>2.0.ZU;2-8
Abstract
The induction of DNA photoproducts in rat corneal epithelium was studi ed after in vivo exposure to different doses of ultraviolet B light at 297 nm. Affinity-purified antibodies with a major specificity against UV-induced (6-4) photoproducts were used. The results indicate a dose dependent formation of (6-4) photoproducts. Even a minimal erythema d ose (25 mJ/cm(2)) produced (6-4) photoproducts, demonstrating that DNA damage occurs in corneal tissue following exposure to biologically re levant doses of UVB light.