Synthesis and structure-affinity relationships at the central benzodiazepine receptor of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines

Authors
Campagna, F Palluotto, F Carotti, A Casini, G Genchi, G
Citation
F. Campagna et al., Synthesis and structure-affinity relationships at the central benzodiazepine receptor of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines, BIO MED CH, 7(8), 1999, pp. 1533-1538
Citations number
28
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
7
Issue
8
Year of publication
1999
Pages
1533 - 1538
Database
ISI
SICI code
0968-0896(199908)7:8<1533:SASRAT>2.0.ZU;2-R
Abstract
A series of 2-aryl-3-chloro-2H-pyridazino[4,3-b]indoles, 2-aryl-3-methoxy-2 H-pyridazino[4,3-b]indoles, and 2-aryl-2,5-dihydroindeno[1,2-c]pyridazino-3 (3H)-ones has been prepared and tested for their ability to inhibit the [3H ]flunitrazepam binding to the central benzodiazepine receptor. SAR are pres ented and discussed in comparison with existing pharmacophore models. (C) 1 999 Elsevier Science Ltd. All rights reserved.