Imidazothiadiazine dioxides: Synthesis and antiviral activity

Authors
Martinez, A Esteban, AI Herrero, A Ochoa, C Andrei, G Snoeck, R Balzarini, J De Clercq, E
Citation
A. Martinez et al., Imidazothiadiazine dioxides: Synthesis and antiviral activity, BIO MED CH, 7(8), 1999, pp. 1617-1623
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
7
Issue
8
Year of publication
1999
Pages
1617 - 1623
Database
ISI
SICI code
0968-0896(199908)7:8<1617:IDSAAA>2.0.ZU;2-Q
Abstract
A new series of imidazothiadiazine dioxides, including the first acyclonucl eosides derived from this heterocycle moiety, has been synthesized. A wide- spectrum antiviral screening was performed. Some of the N-1 benzyl imidazot hiadiazines and the new acyclonucleosides showed interesting anti-CMV or an ti-HIV activity. These structures could be considered as new lead compounds for antiviral drug research. (C) 1999 Elsevier Science Ltd. All rights res erved.