Electrochemical and esr spin trap studies of a new iron tetra- catecholamide complex.

Authors
Cheraiti, N Brik, ME Keita, B Nadjo, L Gaudemer, A
Citation
N. Cheraiti et al., Electrochemical and esr spin trap studies of a new iron tetra- catecholamide complex., BIOORG MED, 9(16), 1999, pp. 2315-2320
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
16
Year of publication
1999
Pages
2315 - 2320
Database
ISI
SICI code
0960-894X(19990816)9:16<2315:EAESTS>2.0.ZU;2-G
Abstract
A new siderophore, N5,N6-thiodipropanoyl-bis[N1,N10-bis(2,3-dihydroxy benzo yl-spermidine)]-Fe (III) complex or H2LFe has been synthesised. The reactio n of the reduced form of this complex with dioxygen has been investigated t hrough electrochemical study and revealed the formation of a new species as sumed to be H2O2. This species has been confirmed by esr spectroscopy using the diamagnetic compound 5-deutero-2,2,5-trimethylpyrrolidine-1-hydroxyl a s spin trap. The resulting persistent radical is 5-deutero-2,2,5-trimethylp yrrolidine-1-yloxy (a(N)=16.58 G, a(D)=3.49 G). (C) 1999 Elsevier Science L td. All rights reserved.