Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1a receptor via Pd(0) amination of bromobenzimidazoles

Authors
Lopez-Rodriguez, ML Viso, A Benhamu, B Rominguera, JL Murcia, M
Citation
Ml. Lopez-rodriguez et al., Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1a receptor via Pd(0) amination of bromobenzimidazoles, BIOORG MED, 9(16), 1999, pp. 2339-2342
Citations number
45
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
16
Year of publication
1999
Pages
2339 - 2342
Database
ISI
SICI code
0960-894X(19990816)9:16<2339:SON(WA>2.0.ZU;2-5
Abstract
The synthesis of a new family of (benzimidazolyl)piperazines has been devel oped through Pd(0) mediated amination of 4- and 6-bromobenzimidazole deriva tives. Preliminary studies showed that some of these compounds are potent 5 -HT1A receptor ligands. (C) 1999 Elsevier Science Ltd. All rights reserved.