Structure-based design and synthesis of a novel class of Src SH2 inhibitors

Authors
Buchanan, JL Bohacek, RS Luke, GP Hatada, M Lu, XD Dalgarno, DC Narula, SS Yuan, R Holt, DA
Citation
Jl. Buchanan et al., Structure-based design and synthesis of a novel class of Src SH2 inhibitors, BIOORG MED, 9(16), 1999, pp. 2353-2358
Citations number
33
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
16
Year of publication
1999
Pages
2353 - 2358
Database
ISI
SICI code
0960-894X(19990816)9:16<2353:SDASOA>2.0.ZU;2-9
Abstract
The structure-based design and synthesis of a novel class of 2,4-disubstitu ted thiazoles as Src SH2 inhibitors is described. Initial results are prese nted, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2. (C) 1999 Elsevier Science Ltd. All rights reserved.