Synthesis and estrogen receptor binding affinity of a porphyrin-estradiol conjugate for targeted photodynamic therapy of cancer

Authors
James, DA Swamy, N Paz, N Hanson, RN Ray, R
Citation
Da. James et al., Synthesis and estrogen receptor binding affinity of a porphyrin-estradiol conjugate for targeted photodynamic therapy of cancer, BIOORG MED, 9(16), 1999, pp. 2379-2384
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
16
Year of publication
1999
Pages
2379 - 2384
Database
ISI
SICI code
0960-894X(19990816)9:16<2379:SAERBA>2.0.ZU;2-I
Abstract
A tetraphenylporphyrin-C-11-beta-estradiol conjugate has been synthesized. Competitive binding assay of the conjugate with estrogen receptor (ER)-liga nd-binding domain showed that the conjugate binds specifically to the prote in with high affinity. Potential use of this conjugate to selectively deliv er cytotoxic porphyrins to ER-positive cells in various carcinomas is discu ssed. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.