NMR-based discovery of phosphotyrosine mimetics that bind to the Lck SH2 domain

Authors
Hajduk, PJ Zhou, MM Fesik, SW
Citation
Pj. Hajduk et al., NMR-based discovery of phosphotyrosine mimetics that bind to the Lck SH2 domain, BIOORG MED, 9(16), 1999, pp. 2403-2406
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
16
Year of publication
1999
Pages
2403 - 2406
Database
ISI
SICI code
0960-894X(19990816)9:16<2403:NDOPMT>2.0.ZU;2-5
Abstract
Using an NMR-based screen, a series of novel phosphotyrosine mimetics were discovered that bind to the SH2 domain of Lck. These compounds may serve as useful leads for the design of nonpeptide inhibitors of SH2 domains with i mproved bioavailability and metabolic stability compared to the natural lig ands that contain phosphotyrosine. (C) 1999 Elsevier Science Ltd. All right s reserved.