8-aminoquinolines as anticoccidials - Part III

Authors
Armer, RE Barlow, JS Chopra, N Dutton, CJ Greenway, DHJ Greenwood, SDW Lad, N Shaw, J Thompson, AP Thong, KW Tommasini, I
Citation
Re. Armer et al., 8-aminoquinolines as anticoccidials - Part III, BIOORG MED, 9(16), 1999, pp. 2425-2430
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
16
Year of publication
1999
Pages
2425 - 2430
Database
ISI
SICI code
0960-894X(19990816)9:16<2425:8AA-PI>2.0.ZU;2-W
Abstract
Analogues of the antimalarial pentaquine, 1, in which the nature of the sid e-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the i nter-nitrogen distance and the nature of the terminal amino group were inve stigated. Novel analogues of equal or improved efficacy in vitro and in viv o to pentaquine were discovered. (C) 1999 Elsevier Science Ltd. All rights reserved.