Investigations into self-association of vancomycin covalent dimers using surface plasmon resonance technology

Authors
Adamczyk, M Moore, JA Rege, SD Yu, ZG
Citation
M. Adamczyk et al., Investigations into self-association of vancomycin covalent dimers using surface plasmon resonance technology, BIOORG MED, 9(16), 1999, pp. 2437-2440
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
16
Year of publication
1999
Pages
2437 - 2440
Database
ISI
SICI code
0960-894X(19990816)9:16<2437:IISOVC>2.0.ZU;2-N
Abstract
Covalent dimers of vancomycin linked through the vancosamine sugar moieties of the glycopeptide antibiotic have been synthesized in one step in 67-69% yield. The propensity for self-association of these and related vancomycin covalent dimers is evaluated using surface plasmon resonance technology. ( C) 1999 Elsevier Science Ltd. All rights reserved.