Rm. Schelkun et al., Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers, BIOORG MED, 9(16), 1999, pp. 2447-2452
Voltage activated calcium channel (VACC) blockers have been demonstrated to
have utility in the treatment of stroke and pain. A series of aminomethyl
substituted phenol derivatives has been identified with good functional act
ivity and selectivity for N-type VACC's over sodium and potassium channels.
The methods of synthesis and preliminary pharmacology are discussed herein
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