Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers

Authors
Schelkun, RM Yuen, PW Malone, TC Rock, DM Stoehr, S Szoke, B Tarczy-Hornoch, K
Citation
Rm. Schelkun et al., Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers, BIOORG MED, 9(16), 1999, pp. 2447-2452
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
16
Year of publication
1999
Pages
2447 - 2452
Database
ISI
SICI code
0960-894X(19990816)9:16<2447:SABAOS>2.0.ZU;2-F
Abstract
Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional act ivity and selectivity for N-type VACC's over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein . (C) 1999 Published by Elsevier Science Ltd. All rights reserved.