Detection of a Hodgkin/Reed-Sternberg cell specific immunoglobulin gene rearrangement in the serum DNA of a patient with Hodgkin's disease

Authors
Kornacker, M Jox, A Vockerodt, M Tesch, H Bohlen, H Diehl, V Wolf, J
Citation
M. Kornacker et al., Detection of a Hodgkin/Reed-Sternberg cell specific immunoglobulin gene rearrangement in the serum DNA of a patient with Hodgkin's disease, BR J HAEM, 106(2), 1999, pp. 528-531
Citations number
9
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
BRITISH JOURNAL OF HAEMATOLOGY
ISSN journal
00071048 → ACNP
Volume
106
Issue
2
Year of publication
1999
Pages
528 - 531
Database
ISI
SICI code
0007-1048(199908)106:2<528:DOAHCS>2.0.ZU;2-1
Abstract
We analysed multiple serum samples from a patient with mixed cellularity Ho dgkin's disease for the Hodgkin/Reed-Sternberg cell clone-specific rearrang ed Ig gene sequence. The clone-specific sequence could be detected in DNA e xtracted from a serum sample obtained during clinical relapse but not in se rum samples obtained during or after treatment following relapse.