Consistent fusion of MOZ and TIF2 in AML with inv(8)(p11q13)

We have recently cloned the inv(8)(p11q13) in a patient with acute myeloid leukemia (AML), and demonstrated a fusion between the MOZ and TIF2 genes at 8p11 and 8q13, respectively. We have partially characterized a further cas e of AML with the same karyotypic abnormality. Rearrangements were detected by Southern blotting with a TIF2 probe that rr as close to the breakpoint in the original inv(8) case and with a MOZ probe corresponding to the break point cluster region in the t(8;16) (p11;p13). These findings indicate the existence of breakpoint cluster regions within both genes and demonstrate t hat the MOZ-TIF2 fusion is consistently associated with the inv(8)(p11q13). (C) Elsevier Science Inc., 1999. All rights reserved.