Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia

Authors
Bargetzi, MJ Muhlematter, D Tichelli, A Jotterand, M Wernli, M
Citation
Mj. Bargetzi et al., Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia, CANC GENET, 113(1), 1999, pp. 90-92
Citations number
8
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
113
Issue
1
Year of publication
1999
Pages
90 - 92
Database
ISI
SICI code
0165-4608(199908)113:1<90:DT(PAR>2.0.ZU;2-M
Abstract
A 66-year-old Caucasian woman presented with a Philadelphia chromosome posi tive common B-cell acute lymphoblastic leukemia and a dic(9;12) involving t he der(9)t(9;22), a rearrangement so far not observed in acute lymphoblasti c leukemia. The patient was treated for the acute lymphoblastic leukemia, b ut showed refractory disease and died 6 months after initial diagnosis. Thi s case suggests that, in the combination of t(9;22) and dic(9:12), the know n poor prognostic feature of t(9;22) in acute lymphoblastic leukemia may ou tweigh the favorable outcome reported in patients with dic(9:12). (C) Elsev ier Science Inc.. 1999; All rights reserved.