Synthesis of 3-alkyl/aryl-6-(1 '-N-beta-D or alpha-L-acetylated glycopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles

Authors
Yu, JX Liu, FM Lu, WJ Li, YP Tian, LL Liu, YT Liu, C Cai, MS
Citation
Jx. Yu et al., Synthesis of 3-alkyl/aryl-6-(1 '-N-beta-D or alpha-L-acetylated glycopyranosyl)-s-triazolo[3,4-b]-1,3,4-thiadiazoles, CHEM J CH U, 20(8), 1999, pp. 1233-1237
Citations number
17
Categorie Soggetti
Chemistry
Journal title
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN journal
02510790 → ACNP
Volume
20
Issue
8
Year of publication
1999
Pages
1233 - 1237
Database
ISI
SICI code
0251-0790(199908)20:8<1233:SO3'OA>2.0.ZU;2-I
Abstract
3-Alkyl/aryl-4-amino-5-mercapro-1,2,4-triazoles(5)were condensed with 2,3,4 ,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate(3) or 2,3, 4-tri-O-a cetyl-alpha-L-rhamnopyranosyl isothiocyanate(4) in anhydrous EtOH under ref lux to afford 14 novel 3-alkyl/aryl-6- (1'-N-2', 3',4',6'-tetra-O-acetyl-be ta-D-glucopyranosyl or 1'-N-2', 3', 4'-tri-O-acetyl-alpha-L-rhamnopyranosyl )-s-triazolo [3,4-b]-1,3,4-thiadiazoles (6a-6i, 7a-7e). Their structures we re confirmed by elemental analysis, IR and H-1 NMR spectral data.