LOCALIZED GENE-ACTION CONTROLLING INTESTINAL NEOPLASIA IN MICE

Mice heterozygous for the Apc(Min) (Min) mutation develop adenomas thr oughout the intestinal tract. Ape is believed to be involved in cell m igration, adhesion, and polarity. Adenoma multiplicity and growth rate are modulated by an unlinked modifier locus, Mom1. The secretory phos pholipase Pla2g2a is a candidate for Mom1. Here, we investigate the ra nge of action of Apc and Mom1. Analysis of chimeric Min mice indicates that the actions of both Ape and Mom1 are localized within the cell l ineage that gives rise to intestinal tumors.