Tributyltin hydride induced intramolecular aryl radical cyclizations: Synthesis of biologically interesting organic compounds

This review aims to summarize significant advances made in the past few yea rs in the use of tributyltin hydride mediated intramolecular aryl radical c yclizations in the synthesis of various biologically active organic compoun ds, including antibiotics, anti-tumor agents, alkaloids and terpenoids. in contrast to alkyl radical cyclization, it has been shown here that the cycl ization of the aryl radical to the larger ring systems compared to the smal ler ring systems is a favored process in many instances.