A comprehensive review of the applications of transition metal-catalyzed reactions to solid phase synthesis

Transition metal-catalyzed reactions have wide appeal in solid phase organi c synthesis due to the mild reaction conditions, compatibility with a broad range of functionalities, and high reaction yields. This article presents a comprehensive review of the non-patent literature transition metal-cataly zed reactions on solid support up to the end of 1998. Particular emphasis i s placed on the catalyst, reaction amounts and resin used. The reactions di scussed fall within four main categories: solid phase ruthenium-catalyzed m etathesis chemistry, solid phase palladium-catalyzed coupling (named reacti ons), other solid phase palladium-catalyzed reactions and a small section c ontaining applications of rhodium- and other transition metal-mediated reac tions.