Ra. Veitia et al., A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines, CYTOG C GEN, 85(3-4), 1999, pp. 217-220
We have characterized a novel human gene (Cl4orfl) which codes for a polype
ptide homologous to the yeast protein Yer044c. Both the human and yeast pro
teins are predicted to be highly basic and to present several potential, ev
olutionarily conserved, transmembrane domains. Cl4orfl mRNA was found to be
particularly abundant in the adult testis and in several cancer cell lines
. The gene maps to chromosome band 14q24. Further investigations should be
performed to understand the role of C14orfl in the testis and the significa
nce of its strong expression in the cell lines studied here.