A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines

Authors
Veitia, RA Ottolenghi, C Bissery, MC Fellous, A
Citation
Ra. Veitia et al., A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines, CYTOG C GEN, 85(3-4), 1999, pp. 217-220
Citations number
8
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
85
Issue
3-4
Year of publication
1999
Pages
217 - 220
Database
ISI
SICI code
0301-0171(1999)85:3-4<217:ANHGEA>2.0.ZU;2-T
Abstract
We have characterized a novel human gene (Cl4orfl) which codes for a polype ptide homologous to the yeast protein Yer044c. Both the human and yeast pro teins are predicted to be highly basic and to present several potential, ev olutionarily conserved, transmembrane domains. Cl4orfl mRNA was found to be particularly abundant in the adult testis and in several cancer cell lines . The gene maps to chromosome band 14q24. Further investigations should be performed to understand the role of C14orfl in the testis and the significa nce of its strong expression in the cell lines studied here.