Structure and chromosome location of human OGG1

OGG1 (alias MMH) encodes an g-hydroxyguanine glycosylase, functionally homo logous to bacterial mutM. Here, we report its genomic structure and fine ch romosome location. The human OGG1 gene corresponding to the isoform 1 trans cripts, consists of seven exons, spanning 7,421 bps, while an alternative a dditional exon, utilized for isoform 2, is located approximately 9 kb downs tream. TATA-like sequence was not found in the 5'-upstream region, common i n so-called "housekeeping" genes. The last 55 bases of the 3' untranslated region in exon 7 were unexpectedly conserved among species, presumably beca use the 3' end of the CAMK1 gene, which is transcribed convergently on the opposite strand, is overlapped at the 3' end. By radiation hybrid panel map ping, OGG1 was localized between WI-4179 and AFMA216ZG1 at 3p26, proximal t o the VHL gene.