Diagnosis of anaplastic large-cell lymphoma, including multifocal osseous Ki-1 lymphoma, by fine-needle aspiration biopsy

We present the fine-needle aspiration (FNA) findings of 4 cases of anaplast ic (Ki-1) large-cell lymphoma (ALCL). A primary diagnosis of ALCL,vas made on FNA material in 2 cases, of which one was a multifocal osseous Ki-1 lymp homa. In the other 2 patients who had a known history of ALCL, FNA was used to detect recurrent disease. Oz all cases, large discohesive pleomorphic c ells in the absence of lymphoglandular bodies in the background raised the possibility of a nonhematopoietic neoplasm. Immunochemical staining for CD3 0 was positive in all cases. The cytomorphologic and immunochemical feature s are discussed, along with the differential diagnosis of Ki-1 lymphoma. Di agn. Cytopathol. 1999;21:174-179. (C) 1999 Wiley-Liss, Inc.