Risks versus benefits of testosterone therapy in elderly men

'Andropause', like menopause, has received significant attention in recent years. It results in a variety of symptoms experienced by the elderly. Many of these symptoms are nonspecific and vague. For this reason, many authors have questioned the value of androgen replacement in this population. Also in dispute is the normal cutoff level for testosterone beyond which therap y should be initiated, and whether to measure free or total testosterone. T estosterone levels;decline with age, with the lowest level seen in men olde r than 70 years. This age-related decline in testosterone levels is both ce ntral (pituitary) and peripheral (testes) in origin. With aging, there is a lso a loss of circadian rhythm of testosterone secretion and a rise in sex hormone binding globulin (SHBG) levels. Total testosterone level is the bes t screening test for patients with suspected hypogonadism. If the total tes tosterone concentration is low, free testosterone levels should be obtained . Prostate cancer remains an absolute contraindication to androgen therapy. Testosterone replacement results in an improvement in muscle strength and bone mineral density. Similar effects are observed on the haematopoietic sy stem. Data on cognition and lipoprotein profiles are conflicting. Androgen therapy can result in polycythemia and sleep apnoea. These adverse effects can be deleterious in men with compromised cardiac reserve. We recommend th at elderly men with symptoms of hypogonadism and a total testosterone level <300 ng/dl should be started on testosterone replacement. This review disc usses the pros and cons of testosterone replacement in hypogonadal elderly men and attempts to answer some of the unanswered questions. Furthermore, e mphasis is made on the regular follow-up of these patients to prevent the d evelopment of therapy-related complications.