Steady-state model calculations predicting the influence of key parameterson the lower detection limit and ruggedness of solvent polymeric membrane ion-selective electrodes

Using a previously described steady-state model, the influence of various p arameters on the response function of ion-selective electrodes is investiga ted. The parameters studied include activities of interfering ions of the s ample and inner solution, selectivity coefficients, lipophilicily of the an alyte, concentrations of ionophore and lipophilic ionic sites in the membra ne, the thickness of the Nernstian diffusion layer and the membrane as well as the diffusion coefficients in both phases. The results obtained provide indications as to how the lower detection limit of potentiometric sensors and their ruggedness can be improved.