Quantitative mechanistically based dose-response modeling with endocrine-active compounds

A wide range of toxicity lest methods is used or is being developed for ass essing the impact of endocrine-active compounds (EACs) on human hearth. Int erpretation of these data and their quantitative use in human and ecologic risk assessment will be enhanced by the availability of mechanistically bas ed dose-response (MBDR) models to assist tow-dose, interspecies, and in vit ro to in vivo extrapolations. A quantitative dose-response modeling work gr oup examined the state of the art for developing MBDR models for EACs and t he near-term needs to develop, validate, and apply these models for risk as sessments. Major aspects of this report relate to current status of these m odels, the objectives/goals in MBDR model development for EACs, low-dose ex trapolation issues, regulatory inertia impeding acceptance of these approac hes, and resource/data needs to accelerate model development and model acce ptance by the research and the regulatory community.