Outcome of Staphylococcus aureus-triggered sepsis and arthritis in IL-4-deficient mice depends on the genetic background of the host

Authors
Hultgren, O Kopf, M Tarkowski, A
Citation
O. Hultgren et al., Outcome of Staphylococcus aureus-triggered sepsis and arthritis in IL-4-deficient mice depends on the genetic background of the host, EUR J IMMUN, 29(8), 1999, pp. 2400-2405
Citations number
20
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
ISSN journal
00142980 → ACNP
Volume
29
Issue
8
Year of publication
1999
Pages
2400 - 2405
Database
ISI
SICI code
0014-2980(199908)29:8<2400:OOSASA>2.0.ZU;2-L
Abstract
Disruption of the IL-4 gene in two inbred mouse strains revealed a dual rol e of IL-4 in Staphylococcus aureus sepsis and arthritis depending on the ho st's genetic background. IL-4 was protective in 129SV mice, since 5 days af ter S. aureus inoculation IL-4(-/-) mice displayed 70% mortality as compare d to survival of all 129SV wild-type counterparts. On the other hand, IL-4 was detrimental in C57BL/6 mice, since survival of IL-4(-/-) C57BL/6 mice w as increased, as compared to wild-type controls, due to decreased staphyloc occal growth. Altogether our results show the dual role of IL-4 in S. aureu s sepsis and arthritis, depending on the genetic background of the host.