Derivatives of 3-cyano-6-phenyl-4-(3 '-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity

Authors
Krauze, A Germane, S Eberlins, O Sturms, I Klusa, V Duburs, G
Citation
A. Krauze et al., Derivatives of 3-cyano-6-phenyl-4-(3 '-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity, EUR J MED C, 34(4), 1999, pp. 301-310
Citations number
36
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234 → ACNP
Volume
34
Issue
4
Year of publication
1999
Pages
301 - 310
Database
ISI
SICI code
0223-5234(199904)34:4<301:DO3'AT>2.0.ZU;2-W
Abstract
3-Cyano-6-phenyl-4-(3'-pyridyl)pyridine-2(1H)-thione, the related 2,2'-bis- pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines we re synthesised and their neurotropic activities were examined. Bispyridyldi sulfide exhibited low toxicity (LD50 > 5 000 mg/kg, ICR mice, i.p.) and sel ective antiamesic activity at the doses of 0.05-0.5 mg/kg p.o. This effect was significantly higher than that induced by Piracetam at 50 mg/kg. (C) El sevier, Paris.