2-triazenopyrroles: synthesis and biological activity

Authors
Diana, P Barraja, P Lauria, A Almerico, AM Cirrincione, G Loi, AG Musiu, C Pani, A La Colla, P Marongiu, ME
Citation
P. Diana et al., 2-triazenopyrroles: synthesis and biological activity, EUR J MED C, 34(4), 1999, pp. 353-360
Citations number
31
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234 → ACNP
Volume
34
Issue
4
Year of publication
1999
Pages
353 - 360
Database
ISI
SICI code
0223-5234(199904)34:4<353:2SABA>2.0.ZU;2-2
Abstract
2-Triazenopyrroles were synthesized by coupling the corresponding 2-diazopy rroles with secondary amines and tested for antiproliferative, antifungal, antiviral and antibacterial activities. Derivative 9m was the most cytotoxi c, showing, against leukaemia, lymphoma and carcinoma cell lines, IC50 3.9- 21 mu M and inhibited Cox-B2 and VSV with EC50 10 mu M. Derivative 9j, inst ead, was active against C. albicans with a selectivity index higher than th at of miconazole. (C) Elsevier, Paris.