Metastatic trophoblastic disease following partial hydatidiform mole: Casereport and literature review

A patient with a triploid partial hydatidiform who had lung metastasis is p resented. Complete response was achieved with methotrexate chemotherapy. A review of the literature revealed only 11 previously reported cases. In man y of them clinical data are missing. All had lung metastasis and 1 had in a ddition a metastasis in the vagina. Only 1 of these patients died of diseas e. The others responded well to chemotherapy. Metastatic trophoblastic dise ase following partial mole is very rare but the exact prevalence is not kno wn. Since risk factors for developing metastatic trophoblastic disease subs equent to partial mole are not known, all patients should be followed. (C) 1999 Academic Press.