Core needle biopsy is effective in the initial diagnosis of mediastinal lymphoma

Background and objective. With the development and refinement of guidance m odalities for percutaneous biopsies, many investigators have reported studi es supporting the role of guided core needle biopsy in the diagnosis of med iastinal lymphoma. The aims of this report are to evaluate the efficacy of findings at core needle biopsy of mediastinal masses on patient care and de fine the key determinants of clinical success. Design and Methods. Fluoroscopy-guided (in 75 patients) and computed tomogr aphy-guided (in 8 patients) core needle biopsies were performed in 83 patie nts with mediastinal lymphoma: all but one of the patients were at first di agnosis. All the biopsies were performed using a Menghini needle (from 1.2 mm to 1.8 mm). In the vast majority of cases the 1.8 mm gauge was employed. Results. The overall sensitivity for the diagnosis of lymphoma was 81% (67/ 83 cases). In the remaining 16 patients the lymphoma diagnosis was reached either by mediastinoscopy (11 cases) or anterior mediastinotomy (3 cases) o r core needle biopsy of the lung (1 case); one patient was treated directly after the needle biopsy had been unsuccessful because he needed rapid ther apy. In 77/82 (93%) patients it was possible to assess the specific histoty pe. There was no operative mortality; all the biopsies were performed on an outpatient basis. Interpretation and Conclusions. Our data indicate that core needle biopsy s hould be considered as an effective and safe procedure in the diagnosis of patients with mediastinal lymphoma with the possibility of determining the tumor subtype and subsequent specific treatment. (C) 1999, Ferrata Storti F oundation.