Comparative study of a portable monitor for prothrombin time determination, Coaguchek (R), with three systems for control of oral anticoagulant treatment

Citation
M. Vacas et al., Comparative study of a portable monitor for prothrombin time determination, Coaguchek (R), with three systems for control of oral anticoagulant treatment, HAEMOSTASIS, 28(6), 1998, pp. 321-328
Citations number
15
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMOSTASIS
ISSN journal
03010147 → ACNP
Volume
28
Issue
6
Year of publication
1998
Pages
321 - 328
Database
ISI
SICI code
0301-0147(199811/12)28:6<321:CSOAPM>2.0.ZU;2-3
Abstract
Self-testing of oral anticoagulation is a new possibility related to the de velopment of portable capillary whole blood prothrombin time monitors. The aim of this study was to evaluate one of this monitors, Coaguchek(R), with respect to its comparability with our routine prothrombin time determinatio n system, as well as with the reference manual technique and two thrombopla stins of high sensitivity, Manchester Reagent and one manufactured in our c enter, Thromboplastin Bilbao, in a group of patients on oral anticoagulant treatment. Although a correlation of r = 0.9271 was found between internati onal normalized ratio (INR) values of Coaguchek and our routine method, Neo plastine/STA analyzer, the difference of the INR scatter increased with the magnitude of measurement, being lowest for INR between the portable monito r and Manchester Reagent and Thromboplastin Bilbao, with a similar coeffici ent of correlation, r = 0.8948 and r = 0.8905, respectively. A test was per formed showing a 65.6% agreement with the INR values of the STA analyzer, 6 6.4% with Manchester Reagent and 73.4% with Thromboplastin Bilbao. On the b asis of this correspondence with laboratory prothrombin time results Coaguc hek may be considered as a possible option for monitoring anticoagulated pa tients even though patients should be given instructions and advice as rega rds the management and interpretation of the results.