Macrocyclic spermine alkaloids from Verbascum: Isolation, structure elucidation, and syntheses of the (E/Z)-isomeric pairs (S)-verbasikrine/(S)-isoverbasikrine and (S)-verbamekrine/(S)-isoverbamekrine

Authors
Youhnovski, N Drandarov, K Guggisberg, A Hesse, M
Citation
N. Youhnovski et al., Macrocyclic spermine alkaloids from Verbascum: Isolation, structure elucidation, and syntheses of the (E/Z)-isomeric pairs (S)-verbasikrine/(S)-isoverbasikrine and (S)-verbamekrine/(S)-isoverbamekrine, HELV CHIM A, 82(8), 1999, pp. 1185-1194
Citations number
12
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
82
Issue
8
Year of publication
1999
Pages
1185 - 1194
Database
ISI
SICI code
0018-019X(1999)82:8<1185:MSAFVI>2.0.ZU;2-K
Abstract
The isolation and structure elucidation of the 17-membered macrocyclic sper mine alkaloids (S)-verbasikrine (3), (S)-isoverbasikrine (6), (S)-verbamekr ine (9), and (S)-isoverbamekrine (12) is presented. The syntheses of their racemates are described. The HPLC/APCI-MS analysis of the original total al kaloid extract of Verbascum pseudonobile is presented.