Macrocyclic spermine alkaloids from Verbascum: Isolation, structure elucidation, and syntheses of the (E/Z)-isomeric pairs (S)-verbasikrine/(S)-isoverbasikrine and (S)-verbamekrine/(S)-isoverbamekrine
N. Youhnovski et al., Macrocyclic spermine alkaloids from Verbascum: Isolation, structure elucidation, and syntheses of the (E/Z)-isomeric pairs (S)-verbasikrine/(S)-isoverbasikrine and (S)-verbamekrine/(S)-isoverbamekrine, HELV CHIM A, 82(8), 1999, pp. 1185-1194
The isolation and structure elucidation of the 17-membered macrocyclic sper
mine alkaloids (S)-verbasikrine (3), (S)-isoverbasikrine (6), (S)-verbamekr
ine (9), and (S)-isoverbamekrine (12) is presented. The syntheses of their
racemates are described. The HPLC/APCI-MS analysis of the original total al
kaloid extract of Verbascum pseudonobile is presented.