Gould-Jacob type of reaction in the synthesis of thieno[3,2-e]pyrimido[1,2-c]pyramidines: A comparison of classical heating vs solvent-free microwaveirradiation
Cg. Dave et Rd. Shah, Gould-Jacob type of reaction in the synthesis of thieno[3,2-e]pyrimido[1,2-c]pyramidines: A comparison of classical heating vs solvent-free microwaveirradiation, HETEROCYCLE, 51(8), 1999, pp. 1819-1826
Gould-Jacob type of reaction for the synthesis of thieno[3,2-e]pyrimido[1,2
-c]pyrimidines ((5) under bar) has been carried out conventionally by the c
ondensation between 4-aminothieno[2,3-d]pyrimidines ((2) under bar) and die
thyl ethoxymethyl-enemalonate ((3) under bar) via acyclic intermediates die
thyl N-[5,6-disubstituted thieno[2,3-d]pyrimidin-4-yl]aminomethylenemalonat
es ((4) under bar) and the results obtained were compared with single step
microwave technique under solvent free conditions for the synthesis of 5.