Nucleophilic substitution reaction of 3-acetyl-1-methoxyindole and its application for the synthesis of novel 2-substituted methyl 2,3-dihydro-1-methyl-3-oxo-5H-pyrido-[4,3-b]indole-4-carboxylates

Authors
Somei, M Nakajou, M Teramoto, T Tanimoto, A Yamada, F
Citation
M. Somei et al., Nucleophilic substitution reaction of 3-acetyl-1-methoxyindole and its application for the synthesis of novel 2-substituted methyl 2,3-dihydro-1-methyl-3-oxo-5H-pyrido-[4,3-b]indole-4-carboxylates, HETEROCYCLE, 51(8), 1999, pp. 1949-1956
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
51
Issue
8
Year of publication
1999
Pages
1949 - 1956
Database
ISI
SICI code
0385-5414(19990801)51:8<1949:NSRO3A>2.0.ZU;2-A
Abstract
A simple synthetic route was established for 3-acetyl-1-methoxyindole, whic h was found to undergo nucleophilic substitution reactions selectively at t he 2-position. Applying the reaction, novel 2-substituted methyl 2,3-dihydr o-1-methyl-3-oxo-5H-pyrido[4,3-b]indole-4-carboxylates were prepared.